|
KMID : 0370219960400020117
|
|
Yakhak Hoeji
1996 Volume.40 No. 2 p.117 ~ p.125
|
|
|
Synthesis and Antitumor Activity of 3’’-hydroxydaunorubicin and 3’’-hydroxydoxorubicin Derivatives Substituted with 4’’-fluorine or 4’’-azide in Sugar Moiety
|
|
옥광대/Ok KD
박정배/김문성/정동윤/양중익/Park JB/Kim MS/Jung DY/Yang JI
|
|
|
Abstract
|
|
|
|
3’’-Deamino-3’’-hydroxy-4’’-fluoro- or 3’’-deamino-3’’-hydroxy-4’’-azido-daunorubicin(6,8) and -doxorubicin(7,9) have been synthesized, respectively. Compounds 7,8 and 9 were more cytotoxic than daunorubicin(1) and doxorubicin(2) against L1210 murine leukemic cell in vitro. When administered intraperitoneally for 9 days starting 1 day after tumor inoculation, compounds 7(T/C 605%) and 9(T/C 488%) showed significant antitumor activity for ip-inoculuated L1210 murine leukemia at wide range of doses.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|